Breaking in a new function for casein kinase 2

Julio C Morales; Phillip B Carpenter

doi:10.1126/sageke.2004.22.pe24

Breaking in a new function for casein kinase 2

Sci Aging Knowledge Environ. 2004 Jun 2;2004(22):pe24. doi: 10.1126/sageke.2004.22.pe24.

Authors

Julio C Morales¹, Phillip B Carpenter

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of California, University of Texas-Houston Medical School, Houston, TX 77225, USA.

PMID: 15175499
DOI: 10.1126/sageke.2004.22.pe24

Abstract

DNA damage response mechanisms help ensure the fidelity of chromosomal transmission, and the failure of such mechanisms might lead to premature aging and cancer. A new report has established that casein kinase 2 (CK2), a protein that functions in diverse cellular processes, controls the activity of the DNA repair protein XRCC1. These results indicate that CK2 is a key participant in the cellular response to DNA damage.

Publication types

Review

MeSH terms

Animals
Casein Kinase II
DNA Repair / physiology*
DNA-Binding Proteins / metabolism
DNA-Binding Proteins / physiology
Humans
Phosphorylation
Protein Serine-Threonine Kinases / metabolism
Protein Serine-Threonine Kinases / physiology*
X-ray Repair Cross Complementing Protein 1

Substances

DNA-Binding Proteins
X-ray Repair Cross Complementing Protein 1
XRCC1 protein, human
Casein Kinase II
Protein Serine-Threonine Kinases