Abstract
Syntheses and excellent anti-inflammatory effects of a series of novel acanthoic acid analogs are reported. In particular, the mechanistic basis for their anti-inflammatory effects is also described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemical synthesis*
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Abietanes / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cells, Cultured
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Cyclooxygenase Inhibitors / metabolism
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Diterpenes / chemical synthesis*
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Diterpenes / pharmacology
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Edema / metabolism
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Models, Chemical
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Nitric Oxide / antagonists & inhibitors
Substances
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Abietanes
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Diterpenes
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acanthoic acid
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pimarane
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Nitric Oxide