Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections are an emerging problem. Although most liver abscesses are caused by Escherichia coli and Klebsiella pneumoniae, S. aureus can occasionally be isolated as the pathogenic organism. Liver abscess caused by MRSA is rarely reported. Here, we report a case of liver abscess due to MRSA in a 34-year-old man with end-stage renal disease and a 13-year history of hemodialysis treatment.