Heteronuclear selective refocusing 2D NMR experiments for the spectral analysis of enantiomers in chiral oriented solvents

Magn Reson Chem. 2004 Jul;42(7):594-9. doi: 10.1002/mrc.1399.

Abstract

We report the use of carbon-proton heteronuclear selective refocusing 2D NMR experiments dedicated to the spectral analysis of enantiomers dissolved in weakly ordering chiral liquid crystalline solvents. The method permits the extraction of carbon-proton residual dipolar couplings for each enantiomer from a complex or unresolved proton-coupled 13C spectral patterns. Illustrative examples are analysed and discussed. It is shown that an accurate determination of enantiomeric excess is possible.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Isomerism*
  • Models, Chemical*
  • Models, Molecular*
  • Molecular Conformation
  • Nuclear Magnetic Resonance, Biomolecular / methods*
  • Propane / analogs & derivatives*
  • Propane / analysis
  • Propane / chemistry*
  • Solutions
  • Solvents / analysis
  • Solvents / chemistry*
  • Stereoisomerism

Substances

  • Solutions
  • Solvents
  • dibromopropane
  • Propane