Splenectomy is a useful method of treatment in some hematological disorders (congenital microspherocytosis, ITP, hypersplenism). However in many clinical situations the unclear prognostic factors, bad patient's condition or non-typical disease's course may impede the decision to splenectomize. We present a history of three successfully splenectomized patients. In each of reported cases the complicated course required detailed disease and treatment analysis. Our results indicate that splenectomy should be considered as a therapeutic option in the thrombocytopenic patients. This group of patients should be immediately referred to specialized centres.