Abstract
We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue in vivo. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our data collected to date show that cancerous bronchial mucosa has a lower capillary oxygenation and a larger average capillary diameter than normal bronchial mucosa.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Adolescent
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Adult
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Aged
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Algorithms*
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Bronchial Neoplasms / diagnosis
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Bronchial Neoplasms / pathology*
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Feasibility Studies
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Fiber Optic Technology / instrumentation
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Humans
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Image Interpretation, Computer-Assisted*
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Middle Aged
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Pilot Projects
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Reproducibility of Results
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Respiratory Mucosa / pathology*
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Sensitivity and Specificity
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Spectrum Analysis / instrumentation
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Spectrum Analysis / methods*
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Tomography, Optical / instrumentation
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Tomography, Optical / methods*