Abstract
The biologic effects of erythropoietin in the central and peripheral nervous system involve the activation of its specific cell surface receptor and corresponding signal transduction pathways. This article reviews the neuroprotective effects of erythropoietin in brain, emphasizing the progress made using in vitro and in vivo research models.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Animals, Newborn
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Brain / drug effects*
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Brain / metabolism
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Erythropoietin / pharmacology*
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Erythropoietin / therapeutic use
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Ganglia, Spinal / drug effects
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Humans
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In Vitro Techniques
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Infant, Newborn
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Neonatology / methods
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Receptors, Erythropoietin / metabolism
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Recombinant Proteins
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Retina / drug effects
Substances
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Neuroprotective Agents
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Receptors, Erythropoietin
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Recombinant Proteins
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Erythropoietin