Prediction of protein folding rates from the amino acid sequence-predicted secondary structure

Dmitry N Ivankov; Alexei V Finkelstein

doi:10.1073/pnas.0402659101

Prediction of protein folding rates from the amino acid sequence-predicted secondary structure

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8942-4. doi: 10.1073/pnas.0402659101. Epub 2004 Jun 7.

Authors

Dmitry N Ivankov¹, Alexei V Finkelstein

Affiliation

¹ Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.

Abstract

We present a method for predicting folding rates of proteins from their amino acid sequences only, or rather, from their chain lengths and their helicity predicted from their sequences. The method achieves 82% correlation with experiment over all 64 "two-state" and "multistate" proteins (including two artificial peptides) studied up to now.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Databases, Protein
Kinetics
Models, Molecular
Protein Folding*
Protein Structure, Secondary
Proteins / chemistry*
Structure-Activity Relationship
Water / chemistry

Substances

Proteins
Water