We evaluated the effectiveness of topical application of an ointment containing 0.1% estrogen for phimosis in children. Fifty children 1 to 12 years old (average age 4 years) presenting to our department with phimosis were enrolled in this study and treated with an estrogen-containing ointment for 4 weeks. The ointment was applied on the narrow preputed skin twice a day by the child's parents. The success rate was 82%. There were no side effects. The application of an estrogen containing ointment is a viable alternative for treating phimosis in children.