Abstract
Seven derivatives of 1,2,3,4-tetrahydro-beta-carbolin-1-one have been prepared. Three of them showed significant central anti-serotonin activity, comparable with that of trazodone or etoperidone. Some structural features were found to be important for the central antiserotonin activity of the investigated class of compounds.
MeSH terms
-
5-Hydroxytryptophan / antagonists & inhibitors
-
Animals
-
Behavior, Animal / drug effects
-
Carbolines / chemical synthesis*
-
Carbolines / pharmacology
-
Chemical Phenomena
-
Chemistry, Physical
-
Male
-
Mice
-
Piperazines / chemical synthesis*
-
Piperazines / pharmacology
-
Serotonin Antagonists / chemical synthesis*
-
Serotonin Antagonists / pharmacology
-
Structure-Activity Relationship
Substances
-
Carbolines
-
Piperazines
-
Serotonin Antagonists
-
5-Hydroxytryptophan