Identification of a novel allele HLA-A*1113 in a Japanese donor

Tissue Antigens. 2004 Jul;64(1):81-3. doi: 10.1111/j.0001-2815.2004.00232.x.

Abstract

Anew HLA-A*11 allele, A*1113, was identified in a healthy Japanese female. She was typed as HLA-A11?, A2, B46, B67, Cw1, Cw7 (Bw6) with unusual serological reactivity of A11, suggesting possible presence of a new A*11 allele. The novel A*1113 allele was identified by haplotypic group-specific allele amplification using A*11 allele-specific primer pairs and sequence-based typing. The A*1113 allele differs from A*11011 by one nucleotide substitution in exon 3 at position 503 (A --> G) which causes an amino acid change in the alfa2 domain at residue 144 (lysine : K --> arginine : R), thus resulting in the unusual serological reactivity.

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Base Sequence
  • DNA / genetics
  • DNA Primers / genetics
  • Female
  • HLA-A Antigens / genetics*
  • Haplotypes
  • Humans
  • Japan
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Sequence Homology, Nucleic Acid

Substances

  • DNA Primers
  • HLA-A Antigens
  • DNA

Associated data

  • GENBANK/AB073216
  • GENBANK/AB073217