Abstract
The report describes a HPA-1a (Zwa)-negative woman with thrombocytopenia and antibodies in serum and eluate from autologous platelets with an operational anti-HPA-1a specificity. The results of the serological investigations were similar to the findings in most patients suffering from post-transfusion purpura. However, the present patient had no history of blood transfusion prior to the unset of purpura and the thrombocytopenia had persisted 6 months before splenectomy.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Human Platelet / immunology*
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Autoantibodies / immunology*
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Autoimmune Diseases / etiology
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / surgery
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Blood Transfusion
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Female
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Humans
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Integrin beta3
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Middle Aged
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Opipramol / adverse effects
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Platelet Membrane Glycoproteins / immunology*
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Purpura, Thrombocytopenic, Idiopathic / etiology
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Purpura, Thrombocytopenic, Idiopathic / immunology*
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Purpura, Thrombocytopenic, Idiopathic / surgery
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Splenectomy
Substances
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Antigens, Human Platelet
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Autoantibodies
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ITGB3 protein, human
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Integrin beta3
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Platelet Membrane Glycoproteins
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Opipramol