Immunogenicity of inactivated hepatitis A vaccine in children with chronic liver disease

Pediatr Infect Dis J. 2004 Jun;23(6):571-4. doi: 10.1097/01.inf.0000130076.33497.6c.

Abstract

One and 6 months after vaccination with hepatitis A virus vaccine (HAVRIX 720 Junior), immunologic responses (anti-hepatitis A virus >/=20 mIU/ml) in children with chronic hepatitis C infection seroprotection were 92% (23/25) and 75% (9/12) in children with chronic hepatitis B infection 87% (21/24) and 88% (15/17) and in healthy children 91% (20/22) at both times. A booster dose induced seroprotection in all children.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chronic Disease
  • Cohort Studies
  • Female
  • Hepatitis A / complications
  • Hepatitis A / immunology*
  • Hepatitis A / prevention & control
  • Hepatitis A Antibodies / immunology*
  • Hepatitis A Vaccines / administration & dosage
  • Hepatitis A Vaccines / immunology*
  • Hepatitis B Antibodies / immunology
  • Hepatitis B, Chronic / immunology
  • Hepatitis B, Chronic / prevention & control
  • Hepatitis C Antibodies / immunology
  • Hepatitis C, Chronic / immunology
  • Hepatitis C, Chronic / prevention & control
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / immunology*
  • Male
  • Prognosis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk Assessment
  • Sensitivity and Specificity
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology

Substances

  • Hepatitis A Antibodies
  • Hepatitis A Vaccines
  • Hepatitis B Antibodies
  • Hepatitis C Antibodies
  • Vaccines, Inactivated