Abstract
Some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes have been synthesized and studied for their antifungal properties against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Aspergillus flavus / drug effects
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Candida albicans / drug effects
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Candida glabrata / drug effects
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Cephalexin / chemistry
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Cephalexin / pharmacology*
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Cobalt / chemistry
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Copper / chemistry
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Furans / chemistry
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Fusarium / drug effects
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Metals / chemistry*
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Microbial Sensitivity Tests
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Microsporum / drug effects
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Nickel / chemistry
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Phenazopyridine / chemistry
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Pyrroles / chemistry
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Salicylates / chemistry
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Schiff Bases / chemistry
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Schiff Bases / pharmacology
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Trichophyton / drug effects
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Zinc / chemistry
Substances
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Antifungal Agents
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Furans
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Metals
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Pyrroles
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Salicylates
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Schiff Bases
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Cobalt
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Copper
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Nickel
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Zinc
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Phenazopyridine
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Cephalexin
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furan