Elevated serum surfactant protein A and D in a case of acute eosinophilic pneumonia

Intern Med. 2004 May;43(5):423-6. doi: 10.2169/internalmedicine.43.423.

Abstract

A 29-year-old man was admitted to our hospital because of fever elevation, dry cough, malaise, skin eruption, and dyspnea with hypoxemia. His serum levels of surfactant protein (SP) -A and SP-D were markedly high, but serum KL-6 was not. He was diagnosed as acute eosinophilic pneumonia (AEP) on the basis of CT imaging, bronchoalveolar lavage findings and the clinical course. He showed good response to steroid therapy and serum levels of SP-A and SP-D returned to almost normal levels. Our experience suggested that serum SP-A and SP-D might be helpful markers for monitoring the clinical course in AEP.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Biomarkers / blood
  • Bronchoalveolar Lavage Fluid / cytology
  • Follow-Up Studies
  • Humans
  • Male
  • Pulmonary Eosinophilia / blood
  • Pulmonary Eosinophilia / diagnosis*
  • Pulmonary Eosinophilia / drug therapy*
  • Pulmonary Surfactant-Associated Protein A / blood*
  • Pulmonary Surfactant-Associated Protein D / blood*
  • Pulmonary Surfactants / blood
  • Radiography, Thoracic
  • Risk Assessment
  • Severity of Illness Index
  • Steroids / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biomarkers
  • Pulmonary Surfactant-Associated Protein A
  • Pulmonary Surfactant-Associated Protein D
  • Pulmonary Surfactants
  • Steroids