Abstract
The synthesis of 4'-alpha-C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Human T-lymphotropic virus 1 / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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Antiviral Agents
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Nucleosides