Abstract
Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>10(4)-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Animals
-
Escherichia coli Proteins / administration & dosage
-
Escherichia coli Proteins / genetics
-
Escherichia coli Proteins / immunology*
-
Mice
-
Mutation
-
Peptide Elongation Factors / administration & dosage
-
Peptide Elongation Factors / genetics
-
Peptide Elongation Factors / immunology*
-
Salmonella Infections, Animal / immunology*
-
Salmonella Infections, Animal / prevention & control
-
Salmonella Vaccines / administration & dosage
-
Salmonella Vaccines / genetics
-
Salmonella Vaccines / immunology*
-
Salmonella typhimurium / genetics
-
Salmonella typhimurium / pathogenicity*
-
Trans-Activators / administration & dosage
-
Trans-Activators / genetics
-
Trans-Activators / immunology*
-
Virulence
Substances
-
Escherichia coli Proteins
-
Peptide Elongation Factors
-
RfaH protein, E coli
-
Salmonella Vaccines
-
Trans-Activators