Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: comparison with peptidoglycan

Eva Mattsson; Thomas Hartung; Siegfried Morath; Arne Egesten

doi:10.1128/IAI.72.7.4322-4326.2004

Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: comparison with peptidoglycan

Infect Immun. 2004 Jul;72(7):4322-6. doi: 10.1128/IAI.72.7.4322-4326.2004.

Authors

Eva Mattsson¹, Thomas Hartung, Siegfried Morath, Arne Egesten

Affiliation

¹ Department of Clinical Microbiology, University Hospital Utrecht, Heidelberglaan 100, P.O. Box 85.500, 3508 GA Utrecht, Holland. [email protected]

Abstract

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.

Publication types

Comparative Study

MeSH terms

Blood / drug effects
Blood Coagulation / drug effects*
Coagulants / pharmacology*
Humans
Lipopolysaccharides / pharmacology*
Monocytes / drug effects*
Peptidoglycan / pharmacology
Staphylococcus aureus / metabolism
Teichoic Acids / pharmacology*
Thromboplastin / biosynthesis
Thromboplastin / drug effects*
Thromboplastin / genetics

Substances

Coagulants
Lipopolysaccharides
Peptidoglycan
Teichoic Acids
lipoteichoic acid
Thromboplastin