Abstract
Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.
MeSH terms
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Bacterial Proteins
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Calcium / metabolism
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Docosahexaenoic Acids / pharmacology*
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Eicosapentaenoic Acid / pharmacology*
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Humans
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Inflammation / drug therapy*
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Oxidants / metabolism
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Streptolysins / metabolism*
Substances
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Bacterial Proteins
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Oxidants
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Streptolysins
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plY protein, Streptococcus pneumoniae
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Docosahexaenoic Acids
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Eicosapentaenoic Acid
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Calcium