Abstract
Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dendritic Cells / immunology*
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Dendritic Cells / virology
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Genetic Vectors*
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Glycoproteins / genetics
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Glycoproteins / immunology
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Glycoproteins / metabolism
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Green Fluorescent Proteins
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Humans
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Lentivirus / genetics*
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Luminescent Proteins / genetics
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Luminescent Proteins / immunology
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Luminescent Proteins / metabolism
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Lymphocytic Choriomeningitis / immunology*
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Lymphocytic Choriomeningitis / prevention & control
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Lymphocytic choriomeningitis virus / immunology
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Lymphocytic choriomeningitis virus / pathogenicity
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Mice
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Mice, Inbred C57BL
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Recombinant Fusion Proteins / immunology
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T-Lymphocytes, Cytotoxic / immunology
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Transduction, Genetic*
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Viral Vaccines / administration & dosage
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Viral Vaccines / genetics
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Viral Vaccines / immunology
Substances
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Glycoproteins
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Luminescent Proteins
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Recombinant Fusion Proteins
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Viral Vaccines
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Green Fluorescent Proteins