Abstract
The new, cytotoxic dibromotyrosine-derived metabolite psammaplysin C [3], in addition to the two known psammaplysins A [1] and B [2], was isolated from the marine sponge Druinella purpurea. All three compounds were found to possess moderate in vitro cytotoxicity towards the human colon tumor cell-line HCT116.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Colonic Neoplasms / drug therapy
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Porifera / chemistry*
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology*
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Tumor Cells, Cultured / drug effects
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Tyrosine / analogs & derivatives*
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Antineoplastic Agents
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Spiro Compounds
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psammaplysin C
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Tyrosine