Abstract
The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing linker at various positions of the taxoid framework have been prepared to investigate the most suitable position for conjugation. A second series of taxoids modified at the C-2 position aimed at increasing the potency of these taxanes has also been prepared.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Monoclonal* / chemistry
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Antibodies, Monoclonal* / toxicity*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival
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Drug Delivery Systems
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Drug Design
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Drug Screening Assays, Antitumor
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Humans
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Models, Molecular
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Molecular Structure
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Paclitaxel / toxicity
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Structure-Activity Relationship
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Taxoids / chemical synthesis*
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Taxoids / toxicity*
Substances
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Antibodies, Monoclonal
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Antineoplastic Agents
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Taxoids
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Paclitaxel