A case of a 26-year-old male with a two-week history of increased dyspnea, weakness and depressed physical tolerance, is presented. Dilated cardiomyopathy due to cardiotoxic effects of toluene was diagnosed. Echocardiography showed left ventricular ejection fraction of 15%. Standard pharmacological treatment, including amiodarone administered due to atrial fibrillation, caused constant clinical improvement, return of sinus rhythm and increase in the ejection fraction to 45%.