Abstract
In this study we demonstrate that partially purified Pasteurella haemolytica leukotoxin inhibits the proliferative response of bovine peripheral blood mononuclear cells (PBMC) to mitogens in vitro. Inhibition of PBMC proliferation did not appear to be due to cell death. Addition of a neutralizing anti-leukotoxin monoclonal antibody restored a normal proliferative response.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacterial Toxins / pharmacology*
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Cattle
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Cell Division / physiology
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Concanavalin A / pharmacology
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Exotoxins / physiology*
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In Vitro Techniques
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Leukocytes, Mononuclear / cytology*
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Mannheimia haemolytica / pathogenicity*
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Mitogens / antagonists & inhibitors*
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Phytohemagglutinins
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Pokeweed Mitogens
Substances
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Bacterial Toxins
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Exotoxins
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Mitogens
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Phytohemagglutinins
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Pokeweed Mitogens
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leukotoxin
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Concanavalin A