Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Nat Rev Immunol. 2004 Jul;4(7):541-52. doi: 10.1038/nri1395.

Authors

Jayanta Chaudhuri¹, Frederick W Alt

Affiliation

¹ Howard Hughes Medical Institute, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA.

PMID: 15229473
DOI: 10.1038/nri1395

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cytidine Deaminase
Cytosine Deaminase / physiology*
DNA Repair
Deamination
Genes, Immunoglobulin
Humans
Immunoglobulin Class Switching* / genetics
Immunoglobulin Heavy Chains / genetics
Macromolecular Substances
Mice
Models, Genetic
Plasmids / genetics
Somatic Hypermutation, Immunoglobulin / genetics
Transcription, Genetic
VDJ Recombinases / physiology

Substances

Immunoglobulin Heavy Chains
Macromolecular Substances
VDJ Recombinases
AICDA (activation-induced cytidine deaminase)
Cytosine Deaminase
Cytidine Deaminase