Botulinum toxin for the treatment of congenital entropion

Am J Ophthalmol. 2004 Jul;138(1):153-5. doi: 10.1016/j.ajo.2004.02.023.

Abstract

Purpose: To describe a case of congenital entropion presenting with ulcerative keratitis that was successfully treated with a single injection of botulinum toxin.

Design: Interventional case report.

Methods: A 3-week-old female infant with a corneal ulcer of the left eye since birth presented for evaluation. She was found to have entropion of the left lower lid. The pretarsal orbicularis muscle was injected with 5 units of botulinum toxin.

Results: Four days after treatment, the entropion had resolved and the corneal epithelial defect had healed. There was no recurrence of the entropion 7 months after botulinum toxin injection.

Conclusions: Injection of botulinum toxin can effectively treat certain cases of congenital entropion.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Botulinum Toxins, Type A / therapeutic use*
  • Corneal Ulcer / drug therapy
  • Corneal Ulcer / etiology
  • Entropion / complications
  • Entropion / congenital*
  • Entropion / drug therapy*
  • Female
  • Humans
  • Infant, Newborn
  • Injections, Intramuscular
  • Neuromuscular Agents / therapeutic use*
  • Oculomotor Muscles / drug effects

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A