Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria

Southeast Asian J Trop Med Public Health. 1992 Mar;23(1):59-63.

Abstract

Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days. On a drug-sensitive Plasmodium berghei ANKA strain, pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). On a moderately chloroquine-resistant P. berghei NS line, the order of effects was the same, PND greater than ADQ greater than MFQ greater than QHS. On a highly pyronaridine-resistant P. berghei RP line, ADQ, MFQ and QHS showed cross resistance with PND.

Publication types

  • Comparative Study

MeSH terms

  • Amodiaquine / administration & dosage
  • Amodiaquine / therapeutic use*
  • Animals
  • Antimalarials / administration & dosage
  • Antimalarials / therapeutic use*
  • Artemisinins*
  • Drug Administration Schedule
  • Drug Evaluation, Preclinical
  • Drug Resistance
  • Female
  • Malaria / drug therapy*
  • Malaria / mortality
  • Malaria / parasitology
  • Male
  • Mefloquine / administration & dosage
  • Mefloquine / therapeutic use*
  • Mice
  • Naphthyridines / administration & dosage
  • Naphthyridines / therapeutic use*
  • Plasmodium berghei*
  • Sesquiterpenes / administration & dosage
  • Sesquiterpenes / therapeutic use*

Substances

  • Antimalarials
  • Artemisinins
  • Naphthyridines
  • Sesquiterpenes
  • Amodiaquine
  • artemisinin
  • pyronaridine
  • Mefloquine