Abstract
Doublecortin is a microtubule-associated protein that is essential for normal brain development. A recent report published in Molecular Cell shows that doublecortin associates preferentially with microtubules made of 13 protofilaments, by recognizing a novel site between the protofilaments. These findings explain how doublecortin stabilizes microtubules and provide clues about its function during neuronal migration.
MeSH terms
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Actin Cytoskeleton / metabolism
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Actin Cytoskeleton / ultrastructure
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Animals
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Brain / cytology
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Brain / embryology*
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Brain / metabolism
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Cell Differentiation / physiology
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Cell Movement / physiology*
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Doublecortin Domain Proteins
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Humans
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Microtubule-Associated Proteins / metabolism*
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Microtubules / metabolism*
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Neurons / cytology
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Neurons / metabolism*
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Neuropeptides / metabolism*
Substances
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Doublecortin Domain Proteins
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Microtubule-Associated Proteins
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Neuropeptides