Evidence suggests that inadequate access to information and ineffective communication are proximal causes of errors and other adverse events in-patient care. Within the context of reducing these proximal causes of errors, we explore the use of novel information-based approaches to improve information access and communication in health care settings. This paper describes the approaches for and the design of extensions to a clinical information system used to improve information access and communication at the point of care using information-based handheld wireless applications. These extensions include clinical and information resources, event monitoring, and a virtual whiteboard (VWB).