Abstract
A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / pharmacology*
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Animals
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Carboxylic Acids / chemical synthesis
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Carboxylic Acids / pharmacology
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Drug Evaluation, Preclinical
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Male
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Molecular Structure
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Motor Activity / drug effects
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Motor Activity / physiology
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Nicotinic Acids / chemical synthesis*
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Nicotinic Acids / pharmacology*
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Pain Measurement / drug effects*
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Pyridines / chemistry
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Rats
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Rats, Sprague-Dawley
Substances
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Analgesics
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Carboxylic Acids
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Nicotinic Acids
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Pyridines
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trifluoromethylpyridine