Abstract
Lipodystrophy in patients with HIV-infection has been studied intensively to understand its epidemiology and pathophysiology. Recently its development was attributed to a dysregulation of TNF-alpha synthesis' homeostasis by HAART. A few years ago it was found that pentoxifylline decreases TNF-alpha production. We describe one HIV-infected patient, with lipodystrophy syndrome, treated with pentoxifylline without any improvement of lipodystrophic symptoms.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Antiretroviral Therapy, Highly Active / adverse effects*
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HIV Infections / drug therapy*
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HIV-Associated Lipodystrophy Syndrome / chemically induced
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HIV-Associated Lipodystrophy Syndrome / drug therapy*
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HIV-Associated Lipodystrophy Syndrome / metabolism
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Humans
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Male
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Pentoxifylline / therapeutic use*
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Treatment Failure
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Tumor Necrosis Factor-alpha / drug effects*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Tumor Necrosis Factor-alpha
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Pentoxifylline