Abstract
We have compared the effect of two distinct Ih inhibitors on the temporal properties of the ERG response that, as previously shown, correlates well with the HCN activation in rods. The present results confirm the notion that cilobradine is more effective than zatebradine in inducing bradycardia. Importantly, the doses of cilobradine that reduce the heart rate to values comparable to, or lower than, those obtained with higher doses of zatebradine have little effect on the frequency response of the ERG. While more potent than zatebradine in its bradycardic action, cilobradine appears comparatively less effective on the visual response. A possible explanation is that the affinity of cilobradine for the HCN channels in the heart is higher than that for the HCN channels of retinal neurons.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzazepines / pharmacology*
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Bradycardia / chemically induced
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Cardiotonic Agents / pharmacology
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Dose-Response Relationship, Drug
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Electroretinography / drug effects
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Heart / drug effects*
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Heart / physiology
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Heart Rate / drug effects
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Heart Rate / physiology
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Ion Channels / drug effects*
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Ion Channels / physiology
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Membrane Potentials / drug effects
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Membrane Potentials / physiology
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Piperidines / pharmacology
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Rats
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Rats, Long-Evans
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Retina / drug effects*
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Retina / physiology
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Retinal Ganglion Cells / drug effects
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Retinal Ganglion Cells / physiology
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Retinal Rod Photoreceptor Cells / drug effects
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Retinal Rod Photoreceptor Cells / physiology
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Tachycardia / drug therapy
Substances
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Benzazepines
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Cardiotonic Agents
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Ion Channels
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Piperidines
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cilobradine
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zatebradine