Abstract
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Amyloid Precursor Protein Secretases
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Apolipoproteins E / genetics
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Female
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Finland / epidemiology
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Genes, Dominant
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Genetic Predisposition to Disease
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Genotype
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Haplotypes / genetics
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Humans
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Male
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Membrane Glycoproteins / genetics*
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Membrane Proteins / genetics
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Middle Aged
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Polymorphism, Single Nucleotide*
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Presenilin-1
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Presenilin-2
Substances
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Apolipoproteins E
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Membrane Glycoproteins
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Membrane Proteins
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PSEN1 protein, human
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PSEN2 protein, human
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Presenilin-1
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Presenilin-2
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nicastrin protein
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Amyloid Precursor Protein Secretases