Abstract
Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Line
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Cell Transformation, Neoplastic*
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DNA-Binding Proteins / metabolism*
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Enzyme Activation
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Epithelial Cells / cytology
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Epithelial Cells / metabolism*
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Female
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Gene Expression Regulation, Enzymologic
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Humans
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Mammary Glands, Human / cytology*
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Matrix Metalloproteinase 9 / metabolism*
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Protein Isoforms / metabolism
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STAT3 Transcription Factor
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Trans-Activators / metabolism*
Substances
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DNA-Binding Proteins
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Protein Isoforms
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STAT3 Transcription Factor
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STAT3 protein, human
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Trans-Activators
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Matrix Metalloproteinase 9