Catalytic hydroamination of alkynes and norbornene with neutral and cationic tantalum imido complexes

Org Lett. 2004 Jul 22;6(15):2519-22. doi: 10.1021/ol0492851.

Abstract

[reaction: see text] Several tantalum imido complexes have been synthesized and shown to efficiently catalyze the hydroamination of internal and terminal alkynes. An unusual hydroamination/hydroarylation reaction of norbornene catalyzed by a highly electrophilic cationic tantalum imido complex is also reported. Factors affecting catalyst activity and selectivity are discussed along with mechanistic insights gained from stoichiometric reactions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkynes / chemistry*
  • Amination
  • Catalysis
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Norbornanes / chemistry*
  • Organometallic Compounds / chemical synthesis*
  • Tantalum / chemistry*

Substances

  • Alkynes
  • Indicators and Reagents
  • Norbornanes
  • Organometallic Compounds
  • Tantalum