Structural and functional analogue of the active site of polysulfide reductase from Wolinella succinogenes

Inorg Chem. 2004 Jul 26;43(15):4532-3. doi: 10.1021/ic049665i.

Abstract

Synthesis of [PPh4]2[Mo(SPh)2(S2C2(CN)2)2] (2) from [PPh4]2[MoO(S2C2(CN)2)2] (1) has been achieved to mimic the postulated [Mo(S)6] core of polysulfide reductase with two thiolates and two bis(ene-dithiolate) ligands. Compound 2 reacts with polysulfide to yield H2S, modeling the function of polysulfide reductase. The facile conversion of 2 back to 1 in moist solvent suggests that the interconversion of the [MoIV = O] and [MoIV - X] (X = O-Ser, S-Cys, Se-Cys) moieties might occur in the DMSO reductase class of enzymes under appropriate hydrophobic/hydrophilic conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • Cysteine / chemistry
  • Cysteine / metabolism
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Molybdenum / chemistry*
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Oxidoreductases / chemistry*
  • Oxidoreductases / metabolism*
  • Wolinella / enzymology*

Substances

  • Organometallic Compounds
  • Molybdenum
  • Oxidoreductases
  • polysulfide reductase
  • Cysteine