Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

V Sol; P Branland; V Chaleix; R Granet; M Guilloton; F Lamarche; B Verneuil; P Krausz

doi:10.1016/j.bmcl.2004.06.016

Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4207-11. doi: 10.1016/j.bmcl.2004.06.016.

Authors

V Sol¹, P Branland, V Chaleix, R Granet, M Guilloton, F Lamarche, B Verneuil, P Krausz

Affiliation

¹ Université de Limoges, Laboratoire de Chimie des Substances Naturelles, 123, Avenue Albert Thomas, 87060 Limoges, France. [email protected]

PMID: 15261271
DOI: 10.1016/j.bmcl.2004.06.016

Abstract

Twenty four aminoporphyrin derivatives have been tested in vitro for their antibacterial photoactivity against Escherichia coli and Staphylococcus aureus. Two of these compounds, bearing polyamine units, exhibited a significant activity especially against Gram-negative bacteria (E. coli).

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Escherichia coli / drug effects*
Escherichia coli / radiation effects*
Light
Microbial Sensitivity Tests
Porphyrins / chemistry
Porphyrins / pharmacology*
Staphylococcus aureus / drug effects*
Staphylococcus aureus / radiation effects*

Substances

Anti-Bacterial Agents
Porphyrins