P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors

David X Sun; Lifei Liu; Beverly Heinz; Alexander Kolykhalov; Jason Lamar; Robert B Johnson; Q May Wang; Yvonne Yip; Shu-Hui Chen

doi:10.1016/j.bmcl.2004.05.078

P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4333-8. doi: 10.1016/j.bmcl.2004.05.078.

Authors

David X Sun¹, Lifei Liu, Beverly Heinz, Alexander Kolykhalov, Jason Lamar, Robert B Johnson, Q May Wang, Yvonne Yip, Shu-Hui Chen

Affiliation

¹ Lilly Research Laboratory, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

PMID: 15261297
DOI: 10.1016/j.bmcl.2004.05.078

Abstract

We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.

MeSH terms

Amides / chemical synthesis
Amides / chemistry
Amides / pharmacology*
Protease Inhibitors / chemical synthesis
Protease Inhibitors / chemistry
Protease Inhibitors / pharmacology*
Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

Amides
NS3 protein, hepatitis C virus
Protease Inhibitors
Viral Nonstructural Proteins