An optimized CZE method for analysis of mono- and oligomeric aldose mixtures

Carbohydr Res. 2004 Aug 2;339(11):2037-43. doi: 10.1016/j.carres.2004.06.003.

Abstract

An optimized capillary electrophoresis (CZE) method to analyze complex mixtures of aldoses was developed. The approach allows simultaneous quantitative analysis of all four isomeric aldopentoses, eight aldohexoses, as well as xylo- and cellooligosaccharides up to the tetraoses. UV tagging with 4-aminobenzoic acid ethyl ester (ABEE) in combination with reductive amination was used as pre-column derivatization. With optimum baseline separation and short run times, the method is very robust, and especially suited to follow reaction and isomerization kinetics of monosaccharides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Carbohydrate Conformation
  • Electrophoresis, Capillary / methods
  • Hexoses / chemistry
  • Molecular Structure
  • Oligosaccharides / chemistry
  • Pentoses / chemistry
  • Time Factors

Substances

  • Aldehydes
  • Hexoses
  • Oligosaccharides
  • Pentoses