Engineering of functional tendon

Tissue Eng. 2004 May-Jun;10(5-6):755-61. doi: 10.1089/1076327041348464.

Abstract

Surgical tendon repair is limited by the availability of viable tissue for transplantation. Because of its relatively avascular nature, tendon is a prime candidate for engineered tissue replacement. To address this problem, cells isolated from rat Achilles tendon were grown to confluence in culture and allowed to self-assemble into a cylinder between two anchor points. The resulting scaffold-free tissue was composed of aligned, small-diameter collagen fibrils, a large number of cells, and an excess of noncollagenous extracellular matrix; all characteristics of embryonic tendon. The stress-strain response of the constructs also resembles the nonlinear behavior of immature tendons, and the ultimate tensile strength is approximately equal to that of embryonic chick tendon, roughly 2 MPa. These physical and mechanical properties indicate that these constructs are the first viable tendons engineered in vitro, without the aid of artificial scaffolding.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cell Culture Techniques / methods*
  • Cell Proliferation
  • Cells, Cultured
  • Elasticity
  • Fibroblasts / cytology*
  • Fibroblasts / physiology*
  • Rats
  • Rats, Inbred F344
  • Tendons / cytology*
  • Tendons / growth & development*
  • Tensile Strength / physiology
  • Tissue Engineering / methods*