[Recent insights into the implication of ion channels in familial forms of epilepsies associated or non associated to febrile convulsions]

I Gourfinkel-An; S Baulac; R Nabbout; A Brice; M Baulac; E Leguern

doi:10.1016/s0035-3787(04)71011-5

[Recent insights into the implication of ion channels in familial forms of epilepsies associated or non associated to febrile convulsions]

Rev Neurol (Paris). 2004 May;160(5 Pt 2):S90-7. doi: 10.1016/s0035-3787(04)71011-5.

[Article in French]

Authors

I Gourfinkel-An¹, S Baulac, R Nabbout, A Brice, M Baulac, E Leguern

Affiliation

¹ Unité d'Epileptologie, Hôpital Pitié-Salpêtrière, Paris, France.

PMID: 15269666
DOI: 10.1016/s0035-3787(04)71011-5

Abstract

Major advances have recently been made in the understanding of the genetic bases of monogenic inherited epilepsies. For several idiopathic epilepsies, mutations in genes encoding subunits of ion channels or ligand receptors have been demonstrated. This is the case for some generalized idiopathic epilepsies and generalized epilepsies associated with febrile seizures. In this Article, we review the recent clinical and genetic data of these forms of epilepsy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

CLC-2 Chloride Channels
Child
Chloride Channels / genetics
Epilepsy / genetics*
Epilepsy / physiopathology*
Epilepsy, Generalized / genetics
Epilepsy, Generalized / physiopathology
Humans
Ion Channels / physiology*
Mutation / physiology
Myoclonic Epilepsy, Juvenile / genetics
Receptors, GABA-A / genetics
Seizures, Febrile / genetics*
Seizures, Febrile / physiopathology*

Substances

CLC-2 Chloride Channels
Chloride Channels
Ion Channels
Receptors, GABA-A