Abstract
A novel anti-HIV alkaloid, drymaritin (1), and a new C-glycoside flavonoid, diandraflavone (2), along with eight known compounds, torosaflavone A, isovitexin, spinasterol beta-d-glycoside, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, cis-p-coumarate, methyl 5-hydroxy-4-oxopentanoate, and glycerol-alpha-lignocerate, were isolated from Drymaria diandra. Drymaritin (1) exhibited anti-HIV effects in H9 lymphocytes with an EC(50) value of 0.699 microg/mL and a TI of 20.6. Compound 2 showed significantly selective inhibition on superoxide anion generation from human neutrophils stimulated by fMLP/CB with an IC(50) value of 10.0 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology
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Caryophyllaceae / chemistry*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Humans
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Inhibitory Concentration 50
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Lymphocytes / drug effects
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Medicine, Traditional
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Neutrophils / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Taiwan
Substances
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Alkaloids
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Anti-HIV Agents
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Carbolines
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Flavonoids
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diandraflavone
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drymaritin