Possible role of the phosphoinositide pathway for signal transduction in changes in the sensitivity of delta-opiate receptors during diabetes mellitus

Bull Exp Biol Med. 2004 Feb;137(2):147-9. doi: 10.1023/b:bebm.0000028125.22568.aa.
[Article in English, Russian]

Abstract

We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptors during diabetes mellitus.

MeSH terms

  • Benzylidene Compounds / pharmacology
  • Diabetes Mellitus / metabolism*
  • Diglycerides / metabolism
  • Humans
  • In Vitro Techniques
  • Lymphocytes / drug effects
  • Lymphocytes / metabolism
  • Naltrexone / analogs & derivatives*
  • Naltrexone / pharmacology
  • Oligopeptides / pharmacology
  • Phosphatidylinositols / metabolism*
  • Receptors, Opioid, delta / agonists
  • Receptors, Opioid, delta / antagonists & inhibitors
  • Receptors, Opioid, delta / metabolism*
  • Signal Transduction / drug effects

Substances

  • Benzylidene Compounds
  • Diglycerides
  • Oligopeptides
  • Phosphatidylinositols
  • Receptors, Opioid, delta
  • naltrindole benzofuran
  • deltorphin
  • 7-benzylidenenaltrexone
  • Naltrexone