Unusual compulsive motor activity during treatment with clothiapine in a mentally retarded adolescent

Giangennaro Coppola; Eduardo Morelli; Carmela Bravaccio; Rosario Federico; Antonella Gritti

doi:10.1016/j.braindev.2003.11.008

Unusual compulsive motor activity during treatment with clothiapine in a mentally retarded adolescent

Brain Dev. 2004 Sep;26(6):409-11. doi: 10.1016/j.braindev.2003.11.008.

Authors

Giangennaro Coppola¹, Eduardo Morelli, Carmela Bravaccio, Rosario Federico, Antonella Gritti

Affiliation

¹ Clinic of Child Neuropsychiatry, Second University of Naples, Via Pansini, 5, 80131 Naples, Italy. [email protected]

PMID: 15275706
DOI: 10.1016/j.braindev.2003.11.008

Abstract

Atypical antipsychotic agents, specifically those with a high hyposerotonergic activity such as clozapine and clothiapine, have been associated with de novo obsessive-compulsive symptoms. We report the case of a 16-year-old adolescent male with severe mental impairment and disruptive behaviour who developed a compulsive head and body turning disorder on clothiapine. Such a symptom had to be distinguished from epileptic partial seizures; it promptly disappeared with the drug discontinuation.

Publication types

Case Reports

MeSH terms

Adolescent
Antipsychotic Agents / adverse effects
Attention Deficit and Disruptive Behavior Disorders / drug therapy*
Attention Deficit and Disruptive Behavior Disorders / etiology
Compulsive Behavior / chemically induced*
Compulsive Behavior / physiopathology
Diagnosis, Differential
Dibenzothiazepines / adverse effects*
Dose-Response Relationship, Drug
Dyskinesia, Drug-Induced / physiopathology*
Epilepsy, Partial, Motor / diagnosis
Haloperidol / therapeutic use
Humans
Hyperkinesis / chemically induced*
Hyperkinesis / physiopathology
Intellectual Disability / complications*
Intellectual Disability / psychology
Male

Substances

Antipsychotic Agents
Dibenzothiazepines
Haloperidol
clothiapine