Abstract
Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.
MeSH terms
-
Acetylcholine / administration & dosage
-
Analysis of Variance
-
Ascorbic Acid / administration & dosage
-
Blood Flow Velocity
-
Brachial Artery / physiopathology*
-
Case-Control Studies
-
Child
-
Child, Preschool
-
Down Syndrome / complications*
-
Down Syndrome / diagnostic imaging
-
Endothelial Cells
-
Endothelium, Vascular / diagnostic imaging
-
Endothelium, Vascular / drug effects
-
Endothelium, Vascular / physiopathology*
-
Female
-
Humans
-
Male
-
Nitroglycerin / administration & dosage
-
Oxidative Stress / physiology*
-
Probability
-
Reference Values
-
Risk Assessment
-
Ultrasonography, Doppler, Pulsed
-
Vasodilation / drug effects
-
Vasodilation / physiology*
Substances
-
Nitroglycerin
-
Acetylcholine
-
Ascorbic Acid