Abstract
Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Alleles
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Brain Ischemia / epidemiology
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Brain Ischemia / etiology
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Brain Ischemia / genetics
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Cardiovascular Diseases / epidemiology
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Cerebral Hemorrhage / epidemiology
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Cerebral Hemorrhage / genetics*
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Comorbidity
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Diabetes Mellitus / epidemiology
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Genetic Predisposition to Disease
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Genotype
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Humans
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Hypercholesterolemia / epidemiology
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Intracranial Arteriosclerosis / complications
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Intracranial Arteriosclerosis / epidemiology
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Intracranial Arteriosclerosis / genetics
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Middle Aged
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Obesity / epidemiology
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Peptidyl-Dipeptidase A / genetics*
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Poland / epidemiology
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Polymorphism, Genetic*
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Risk Factors
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Smoking / epidemiology