Synthesis of lactoside glycodendrons using photoaddition and reductive amination methodologies

Carbohydr Res. 2004 Aug 23;339(12):2069-75. doi: 10.1016/j.carres.2004.06.011.

Abstract

Carbohydrate-based divalent and tetravalent lactoside glycodendrons were constructed in a convergent manner. The dendrons were synthesized beginning with the photoaddition of hepta-O-acetyl-1-thio-beta-lactose, in an anti-Markovnikov manner, to a bis-allyl AB2 trisaccharide to form a divalent dendron. Following two nearly quantitative deprotection steps, the divalent lactoside was coupled to another AB2 trisaccharide by reductive amination to afford a tetravalent dendron. These paucivalent compounds were characterized by NMR spectroscopy and mass spectrometry.

MeSH terms

  • Amination
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Carbohydrates / chemical synthesis*
  • Carbohydrates / chemistry
  • Galactose / chemical synthesis*
  • Galactose / chemistry
  • Galactose / radiation effects*
  • Glycosides / chemistry*
  • Glycosides / radiation effects*
  • Molecular Sequence Data
  • Oxidation-Reduction
  • Photochemistry

Substances

  • Carbohydrates
  • Glycosides
  • lactosides
  • Galactose