Complexity of the dynamic QT variability and RR variability in patients with acute anterior wall myocardial infarction: a novel technique using a non-linear method

J Electrocardiol. 2004 Jul;37(3):173-9. doi: 10.1016/j.jelectrocard.2004.04.008.

Abstract

QT and RR intervals' fluctuations are implicated in the development of malignant arrhythmias. Recent research has quantified repolarization lability using stochastic and linear methods. However, QT-RR intervals are nonlinearly coupled. To this end, QT and RR intervals were extracted from twenty four patients with acute myocardial infarction (AMI) and 13 controls, and a measure of local dimensional complexity (pointwise correlation dimension, PD2) was calculated. PD2 of QT intervals was significantly higher for the patients than for controls (4.83 +/- 0.81 versus 3.40 +/- 0.76, P =.0001), and vice versa for RR intervals (2.51 +/- 0.62 versus 2.91 +/- 0.42, P =.028). The RR and QT measures of complexity were highly correlated only among controls (r = 0.769, P =.0021). Our results support the presence of autonomic abnormalities during infarction and might complement existing tools for assessment of increased risk for sudden death after AMI.

MeSH terms

  • Algorithms*
  • Autonomic Nervous System / physiopathology
  • Case-Control Studies
  • Electrocardiography*
  • Female
  • Heart Rate / physiology
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / physiopathology*