Acute vanishing bile duct syndrome after ibuprofen therapy in a child

M Taghian; T A Tran; S Bresson-Hadni; A Menget; S Felix; E Jacquemin

doi:10.1016/j.jpeds.2004.05.027

Acute vanishing bile duct syndrome after ibuprofen therapy in a child

J Pediatr. 2004 Aug;145(2):273-6. doi: 10.1016/j.jpeds.2004.05.027.

Authors

M Taghian¹, T A Tran, S Bresson-Hadni, A Menget, S Felix, E Jacquemin

Affiliation

¹ Pediatric Unit, Vesoul Hospital, Vesoul, France.

PMID: 15289784
DOI: 10.1016/j.jpeds.2004.05.027

Abstract

We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy. Liver histology was compatible with vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver tests normalized within 7 months. This report confirms that ibuprofen may induce acute vanishing bile duct syndrome.

Publication types

Case Reports
Review

MeSH terms

Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Bile Duct Diseases / chemically induced*
Bile Duct Diseases / pathology
Bile Ducts, Intrahepatic* / pathology
Child
Cholestasis / chemically induced
Female
Humans
Ibuprofen / adverse effects*
Stevens-Johnson Syndrome / chemically induced
Syndrome

Substances

Anti-Inflammatory Agents, Non-Steroidal
Ibuprofen