Failure of ceftriaxone in an intravenous drug user with invasive infection due to Ralstonia pickettii

C Zellweger; T Bodmer; M G Täuber; K Mühlemann

doi:10.1007/s15010-004-3033-0

Failure of ceftriaxone in an intravenous drug user with invasive infection due to Ralstonia pickettii

Infection. 2004 Aug;32(4):246-8. doi: 10.1007/s15010-004-3033-0.

Authors

C Zellweger¹, T Bodmer, M G Täuber, K Mühlemann

Affiliation

¹ Division of Infectious Diseases, University Hospital, Inselspital PKT2 B, CH-3010 Bern, Switzerland. [email protected]

PMID: 15293083
DOI: 10.1007/s15010-004-3033-0

Abstract

We report a case of septic arthritis due to Ralstonia pickettii in an intravenous drug user with unfavorable clinical course under antibiotic therapy with ceftriaxone despite in vitro susceptibility to the drug. The treatment failure may have been due to a discrepancy between in vitro and in vivo susceptibility of R. pickettii, or to resistance development mediated by a recently described inducible beta-lactamase.

Publication types

Case Reports

MeSH terms

Adult
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use*
Arthritis, Infectious / drug therapy*
Arthritis, Infectious / pathology
Ceftriaxone / pharmacology*
Ceftriaxone / therapeutic use*
Drug Resistance, Bacterial
Gram-Negative Bacterial Infections / drug therapy*
Gram-Negative Bacterial Infections / pathology
Humans
In Vitro Techniques
Male
Microbial Sensitivity Tests
Ralstonia / pathogenicity*
Reproducibility of Results
Substance Abuse, Intravenous*

Substances

Anti-Bacterial Agents
Ceftriaxone